KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR

KDEL receptors are responsible for retrotransporting endoplasmic reticulum (ER) chaperones from the Golgi complex to the ER. Here we describe a role for KDEL receptor 1 (KDELR1) that involves the regulation of integrated stress responses (ISR) in T cells. Designing and using an N-ethyl-N-nitrosourea...

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Publicado no:Nat Commun
Main Authors: Kamimura, Daisuke, Katsunuma, Kokichi, Arima, Yasunobu, Atsumi, Toru, Jiang, Jing-jing, Bando, Hidenori, Meng, Jie, Sabharwal, Lavannya, Stofkova, Andrea, Nishikawa, Naoki, Suzuki, Hironao, Ogura, Hideki, Ueda, Naoko, Tsuruoka, Mineko, Harada, Masaya, Kobayashi, Junya, Hasegawa, Takanori, Yoshida, Hisahiro, Koseki, Haruhiko, Miura, Ikuo, Wakana, Shigeharu, Nishida, Keigo, Kitamura, Hidemitsu, Fukada, Toshiyuki, Hirano, Toshio, Murakami, Masaaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557295/
https://ncbi.nlm.nih.gov/pubmed/26081938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8474
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