Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1

Primary hyperoxaluria type 1 (PH1) is an autosomal recessive, metabolic disorder caused by mutations of alanine-glyoxylate aminotransferase (AGT), a key hepatic enzyme in the detoxification of glyoxylate arising from multiple normal metabolic pathways to glycine. Accumulation of glyoxylate, a precur...

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Udgivet i:Mol Ther
Main Authors: Dutta, Chaitali, Avitahl-Curtis, Nicole, Pursell, Natalie, Larsson Cohen, Marita, Holmes, Benjamin, Diwanji, Rohan, Zhou, Wei, Apponi, Luciano, Koser, Martin, Ying, Bo, Chen, Dongyu, Shui, Xue, Saxena, Utsav, Cyr, Wendy A, Shah, Anee, Nazef, Naim, Wang, Weimin, Abrams, Marc, Dudek, Henryk, Salido, Eduardo, Brown, Bob D, Lai, Chengjung
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886950/
https://ncbi.nlm.nih.gov/pubmed/26758691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.4
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