Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1

Primary hyperoxaluria type 1 (PH1) is an autosomal recessive, metabolic disorder caused by mutations of alanine-glyoxylate aminotransferase (AGT), a key hepatic enzyme in the detoxification of glyoxylate arising from multiple normal metabolic pathways to glycine. Accumulation of glyoxylate, a precur...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Ther
Hauptverfasser: Dutta, Chaitali, Avitahl-Curtis, Nicole, Pursell, Natalie, Larsson Cohen, Marita, Holmes, Benjamin, Diwanji, Rohan, Zhou, Wei, Apponi, Luciano, Koser, Martin, Ying, Bo, Chen, Dongyu, Shui, Xue, Saxena, Utsav, Cyr, Wendy A, Shah, Anee, Nazef, Naim, Wang, Weimin, Abrams, Marc, Dudek, Henryk, Salido, Eduardo, Brown, Bob D, Lai, Chengjung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886950/
https://ncbi.nlm.nih.gov/pubmed/26758691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.4
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge