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Platelet-derived SDF1 primes pulmonary capillary vascular niche to drive lung alveolar regeneration

The lung alveoli regenerate after surgical removal of the left lobe by pneumonectomy (PNX). How this alveolar regrowth/regeneration is initiated remains unknown. We found that activated platelets trigger lung regeneration by supplying stromal cell-derived-factor1 (SDF1/CXCL12). After PNX, platelets...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Rafii, Shahin, Cao, Zhongwei, Lis, Raphael, Siempos, Ilias I., Chavez, Deebly, Shido, Koji, Rabbany, Sina Y., Ding, Bi-Sen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886751/
https://ncbi.nlm.nih.gov/pubmed/25621952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3096
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