Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells

Activation-induced cytidine deaminase (AID), the enzyme responsible for induction of sequence variation in immunoglobulins (Igs) during the process of somatic hypermutation (SHM) and also Ig class switching, can have a potent mutator phenotype in the development of lymphoma. Using various Epstein-Ba...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Kalchschmidt, Jens S., Bashford-Rogers, Rachael, Paschos, Kostas, Gillman, Adam C.T., Styles, Christine T., Kellam, Paul, Allday, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886369/
https://ncbi.nlm.nih.gov/pubmed/27217538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160120
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