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Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice. We foun...
Kaydedildi:
| Yayımlandı: | J Exp Med |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Rockefeller University Press
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4886365/ https://ncbi.nlm.nih.gov/pubmed/27139492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151869 |
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