The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1

Activation of the sensory nerve ion channel TRPA1 by electrophiles is the key mechanism that initiates nociceptive signaling, and leads to defensive reflexes and avoidance behaviors, during oxidative stress in mammals. TRPA1 is rapidly activated by subtoxic levels of electrophiles, but it is unclear...

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Bibliographische Detailangaben
Veröffentlicht in:J Gen Physiol
Hauptverfasser: Bahia, Parmvir K., Parks, Thomas A., Stanford, Katherine R., Mitchell, David A., Varma, Sameer, Stevens, Stanley M., Taylor-Clark, Thomas E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886278/
https://ncbi.nlm.nih.gov/pubmed/27241698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611581
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