The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1

Activation of the sensory nerve ion channel TRPA1 by electrophiles is the key mechanism that initiates nociceptive signaling, and leads to defensive reflexes and avoidance behaviors, during oxidative stress in mammals. TRPA1 is rapidly activated by subtoxic levels of electrophiles, but it is unclear...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Bahia, Parmvir K., Parks, Thomas A., Stanford, Katherine R., Mitchell, David A., Varma, Sameer, Stevens, Stanley M., Taylor-Clark, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886278/
https://ncbi.nlm.nih.gov/pubmed/27241698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611581
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