Formulation optimization of Docetaxel loaded self-emulsifying drug delivery system to enhance bioavailability and anti-tumor activity

Poor bioavailability of Docetaxel (DCT) arising due to its low aqueous solubility and permeability limits its clinical utility. The aim of the present study was to develop DCT loaded self-emulsified drug delivery systems (D-SEDDS) and evaluate its potential ability to improve the oral bioavailabilit...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Valicherla, Guru R., Dave, Kandarp M., Syed, Anees A., Riyazuddin, Mohammed, Gupta, Anand P., Singh, Akhilesh, Wahajuddin, Mitra, Kalyan, Datta, Dipak, Gayen, Jiaur R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4886259/
https://ncbi.nlm.nih.gov/pubmed/27241877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26895
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