Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib

To improve the solubility and oral bioavailability of erlotinib, a poorly water-soluble anticancer drug, solid self-emulsifying drug delivery system (SEDDS) was developed using solid inert carriers such as dextran 40 and Aerosil® 200 (colloidal silica). The preliminary solubility of erlotinib in var...

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Библиографические подробности
Опубликовано в: :AAPS PharmSciTech
Главные авторы: Truong, Duy Hieu, Tran, Tuan Hiep, Ramasamy, Thiruganesh, Choi, Ju Yeon, Lee, Hee Hyun, Moon, Cheol, Choi, Han-Gon, Yong, Chul Soon, Kim, Jong Oh
Формат: Artigo
Язык:Inglês
Опубликовано: Springer US 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984901/
https://ncbi.nlm.nih.gov/pubmed/26238806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-015-0370-5
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