Spontaneous Tumor Development in Bone Marrow Rescued DNA-PKcs(3A/3A) Mice Due to Dysfunction of Telomere Leading Strand Deprotection

Phosphorylation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) at the Thr2609 cluster is essential for its complete function in DNA repair and tissue stem cell homeostasis. This phenomenon is demonstrated by congenital bone marrow failure occurring in DNA-PKcs(3A/3A) mutant mice, w...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zhang, Shichuan, Matsunaga, Shinji, Lin, Yu-Fen, Sishc, Brock, Shang, Zengfu, Sui, Jiangdong, Shih, Hung-Ying, Zhao, Yong, Foreman, Oded, Story, Michael D., Chen, David J., Chen, Benjamin PC.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885801/
https://ncbi.nlm.nih.gov/pubmed/26616856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.459
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