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Mechanistic Modeling of the Effects of Acidosis on Thrombin Generation

BACKGROUND: Acidosis, a frequent complication of trauma and complex surgery, results from tissue hypoperfusion and IV resuscitation with acidic fluids. While acidosis is known to inhibit the function of distinct enzymatic reactions, its cumulative effect on the blood coagulation system is not fully...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Anesth Analg
Main Authors: Mitrophanov, Alexander Y., Rosendaal, Frits R., Reifman, Jaques
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2015
Teme:
30
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885548/
https://ncbi.nlm.nih.gov/pubmed/25839182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000000733
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