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Mechanistic Modeling of the Effects of Acidosis on Thrombin Generation

BACKGROUND: Acidosis, a frequent complication of trauma and complex surgery, results from tissue hypoperfusion and IV resuscitation with acidic fluids. While acidosis is known to inhibit the function of distinct enzymatic reactions, its cumulative effect on the blood coagulation system is not fully...

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Detalhes bibliográficos
Publicado no:Anesth Analg
Main Authors: Mitrophanov, Alexander Y., Rosendaal, Frits R., Reifman, Jaques
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2015
Assuntos:
30
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885548/
https://ncbi.nlm.nih.gov/pubmed/25839182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000000733
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