Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients

Lynch syndrome (LS) is an autosomal-dominant inherited disorder mainly caused by a germline mutation in the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, and PMS2) and is associated with increased risk for various cancers, particularly colorectal cancer and endometrial cancer (EC). Women with L...

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Detalhes bibliográficos
Publicado no:Am J Surg Pathol
Main Authors: Kato, Aya, Sato, Naoki, Sugawara, Tae, Takahashi, Kazue, Kito, Masahiko, Makino, Kenichi, Sato, Toshiharu, Shimizu, Dai, Shirasawa, Hiromistu, Miura, Hiroshi, Sato, Wataru, Kumazawa, Yukiyo, Sato, Akira, Kumagai, Jin, Terada, Yukihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Health, Inc 2016
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885527/
https://ncbi.nlm.nih.gov/pubmed/26848797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0000000000000606
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