Deletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell Responses

MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity of MVA vectors harboring the simultaneous deletion of A44L, related to steroid...

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Veröffentlicht in:Viruses
Hauptverfasser: Holgado, María Pía, Falivene, Juliana, Maeto, Cynthia, Amigo, Micaela, Pascutti, María Fernanda, Vecchione, María Belén, Bruttomesso, Andrea, Calamante, Gabriela, del Médico-Zajac, María Paula, Gherardi, María Magdalena
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885094/
https://ncbi.nlm.nih.gov/pubmed/27223301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v8050139
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