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p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cells

Paclitaxel (PTX) is a chemotherapeutic agent that is used to treat a variety of cancers, including non-small cell lung cancer (NSCLC). However, the emergence of drug resistance limits the utility of PTX. This study determined the signaling pathway that contributes to PTX resistance. We first establi...

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書目詳細資料
發表在:Oncotarget
Main Authors: Park, Shin-Hyung, Seong, Myeong-A, Lee, Ho-Young
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884985/
https://ncbi.nlm.nih.gov/pubmed/26799187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6945
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