Fractionation of a tumor-initiating UV dose introduces DNA damage-retaining cells in hairless mouse skin and renders subsequent TPA-promoted tumors non-regressing

Sunburns and especially sub-sunburn chronic UV exposure are associated with increased risk of squamous cell carcinomas (SCCs). Here we focus on a possible difference in tumor initiation from a single severe-sunburn dose (on day 1, 21 hairless mice) and from an equal dose fractionated into very low s...

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Publicado en:Oncotarget
Autores principales: van de Glind, Gerline, Rebel, Heggert, van Kempen, Marika, Tensen, Kees, de Gruijl, Frank
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884976/
https://ncbi.nlm.nih.gov/pubmed/26797757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6932
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