Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency

STUDY HYPOTHESIS: We hypothesized that the mitochondria of granulosa cells (GC) and/or oocytes might be abnormal in a mouse model of fragile X premutation (FXPM). STUDY FINDING: Mice heterozygous and homozygous for the FXPM have increased death (atresia) of large ovarian follicles, fewer corpora lut...

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Bibliografiset tiedot
Julkaisussa:Mol Hum Reprod
Päätekijät: Conca Dioguardi, Carola, Uslu, Bahar, Haynes, Monique, Kurus, Meltem, Gul, Mehmet, Miao, De-Qiang, De Santis, Lucia, Ferrari, Maurizio, Bellone, Stefania, Santin, Alessandro, Giulivi, Cecilia, Hoffman, Gloria, Usdin, Karen, Johnson, Joshua
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2016
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884918/
https://ncbi.nlm.nih.gov/pubmed/26965313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gaw023
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