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Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase.

Transcription of the murine thymidine kinase gene, which is coregulated with the G1/S phase transition, is activated by changing the binding of protein complexes Yi1 and Yi2 to three upstream DNA motifs. Yi1 is replaced by Yi2 shortly before S phase. Yi1 contains a protein of 110 kDa that binds to t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Dou, Q P, Markell, P J, Pardee, A B
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48845/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1565617/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.8.3256
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