Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis

Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal disease with limited treatment options. Protease mediated transforming growth factor-β (TGF-β) activation has been proposed as a pathogenic mechanism of lung fibrosis. Protease activity in the lung is tightly regulated by protease inhibitor...

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Foilsithe in:Lab Invest
Main Authors: Habgood, Anthony N, Tatler, Amanda L, Porte, Joanne, Wahl, Sharon M, Laurent, Geoffrey J, John, Alison E, Johnson, Simon R, Jenkins, Gisli
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884449/
https://ncbi.nlm.nih.gov/pubmed/26974397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2016.40
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