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Histone H3.3 promotes IgV gene diversification by enhancing formation of AID‐accessible single‐stranded DNA
Immunoglobulin diversification is driven by activation‐induced deaminase (AID), which converts cytidine to uracil within the Ig variable (IgV) regions. Central to the recruitment of AID to the IgV genes are factors that regulate the generation of single‐stranded DNA (ssDNA), the enzymatic substrate...
Tallennettuna:
| Julkaisussa: | EMBO J |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
John Wiley and Sons Inc.
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4883027/ https://ncbi.nlm.nih.gov/pubmed/27220848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201693958 |
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