The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling

Protein ubiquitination controls protein stability and subcellular localization of tyrosine kinase receptors, hence affecting signaling both quantitatively and qualitatively. In this report, we demonstrate that, after ligand stimulation, the PDGF β receptor (PDGFRβ) becomes ubiquitinated in a manner...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Rorsman, Charlotte, Tsioumpekou, Maria, Heldin, Carl-Henrik, Lennartsson, Johan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
Onderwerpen:
Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882431/
https://ncbi.nlm.nih.gov/pubmed/27048651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705814
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