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Phase 1 study of cardiac safety of TAS-102 in patients with advanced solid tumors
PURPOSE: TAS-102 is a novel oral agent combining the antineoplastic thymidine-based nucleoside analogue, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil (molar ratio 1:0.5). TAS-102 has shown good activity in refractory metastatic colorectal cancer with acceptable safety. No QT pr...
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882359/ https://ncbi.nlm.nih.gov/pubmed/27151157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-3031-9 |
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