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LPA/PKD-1-FoxO1 signaling axis mediates endothelial cell CD36 transcriptional repression and proangiogenic and proarteriogenic reprogramming
OBJECTIVE: CD36 is a scavenger and antiangiogenic receptor that is important in atherothrombotic diseases, diabetes, cancer and obesity. Lysophosphatidic acid (LPA), a phospholipid signaling mediator, abolishes endothelial cell responses to antiangiogenic proteins containing thrombospondin type 1 ho...
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| 出版年: | Arterioscler Thromb Vasc Biol |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882231/ https://ncbi.nlm.nih.gov/pubmed/27013613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307421 |
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