Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

Phagocytosis is essential to maintain tissue homeostasis in a large number of inflammatory and autoimmune diseases, but its role in the diseased brain is poorly explored. Recent findings suggest that in the adult hippocampal neurogenic niche, where the excess of newborn cells undergo apoptosis in ph...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Abiega, Oihane, Beccari, Sol, Diaz-Aparicio, Irune, Nadjar, Agnes, Layé, Sophie, Leyrolle, Quentin, Gómez-Nicola, Diego, Domercq, María, Pérez-Samartín, Alberto, Sánchez-Zafra, Víctor, Paris, Iñaki, Valero, Jorge, Savage, Julie C., Hui, Chin-Wai, Tremblay, Marie-Ève, Deudero, Juan J. P., Brewster, Amy L., Anderson, Anne E., Zaldumbide, Laura, Galbarriatu, Lara, Marinas, Ainhoa, Vivanco, Maria dM., Matute, Carlos, Maletic-Savatic, Mirjana, Encinas, Juan M., Sierra, Amanda
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881984/
https://ncbi.nlm.nih.gov/pubmed/27228556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002466
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