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Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes

A DNA fragment containing the promoter of the mouse metallothionein-I gene fused to the structural gene of rat growth hormone was microinjected into the pronuclei of fertilized mouse eggs. Of 21 mice that developed from these eggs, seven carried the fusion gene and six of these grew significantly la...

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Bibliographic Details
Published in:Nature
Main Authors: Palmiter, Richard D., Brinster, Ralph L., Hammer, Robert E., Trumbauer, Myrna E., Rosenfeld, Michael G., Birnberg, Neal C., Evans, Ronald M.
Format: Artigo
Language:Inglês
Published: 1982
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881848/
https://ncbi.nlm.nih.gov/pubmed/6958982
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