Spatial Colocalization and Functional Link of Purinosomes with Mitochondria

Purine biosynthetic enzymes organize into dynamic cellular bodies called purinosomes. Little is known about the spatiotemporal control of these structures. Using super-resolution microscopy, we demonstrated that purinosomes colocalized with mitochondria, and these results were supported by isolation...

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Pubblicato in:Science
Autori principali: French, Jarrod B., Jones, Sara A., Deng, Huayun, Pedley, Anthony M., Kim, Doory, Chan, Chung Yu, Hu, Haibei, Pugh, Raymond J., Zhao, Hong, Zhang, Youxin, Huang, Tony Jun, Fang, Ye, Zhuang, Xiaowei, Benkovic, Stephen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881839/
https://ncbi.nlm.nih.gov/pubmed/26912862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac6054
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