Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington's Disease Mouse Models

Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric disease that causes neuronal death and is characterized by progressive striatal and then widespread brain atrophy. Brain-derived neurotrophic factor (BDNF) is a lead candidate for the treatment of HD, as it ha...

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Vydáno v:Mol Ther
Hlavní autoři: Pollock, Kari, Dahlenburg, Heather, Nelson, Haley, Fink, Kyle D, Cary, Whitney, Hendrix, Kyle, Annett, Geralyn, Torrest, Audrey, Deng, Peter, Gutierrez, Joshua, Nacey, Catherine, Pepper, Karen, Kalomoiris, Stefanos, D Anderson, Johnathon, McGee, Jeannine, Gruenloh, William, Fury, Brian, Bauer, Gerhard, Duffy, Alexandria, Tempkin, Theresa, Wheelock, Vicki, Nolta, Jan A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881765/
https://ncbi.nlm.nih.gov/pubmed/26765769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.12
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