Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing

Transcriptional gene silencing (TGS) of mammalian genes can be induced by short interfering RNA (siRNA) targeting promoter regions. We previously reported potent TGS of HIV-1 by siRNA (PromA), which targets tandem NF-κB motifs within the viral 5′LTR. In this study, we screened a siRNA panel with the...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Ahlenstiel, Chantelle, Mendez, Catalina, Lim, Steven T H, Marks, Katherine, Turville, Stuart, Cooper, David A, Kelleher, Anthony D, Suzuki, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881759/
https://ncbi.nlm.nih.gov/pubmed/26506039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.31
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