Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects

Sirolimus (SRL) and everolimus (EVR) are mammalian targets of rapamycin inhibitors (mTOR-I) largely employed in renal transplantation and oncology as immunosuppressive/antiproliferative agents. SRL was the first mTOR-I produced by the bacterium Streptomyces hygroscopicus and approved for several med...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Granata, Simona, Dalla Gassa, Alessandra, Carraro, Amedeo, Brunelli, Matteo, Stallone, Giovanni, Lupo, Antonio, Zaza, Gianluigi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881557/
https://ncbi.nlm.nih.gov/pubmed/27187382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17050735
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