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Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome

Chromosomal translocations typically impair cell differentiation and often require secondary mutations for malignant transformation. However, the role of a primary translocation in the development of collaborating mutations is debatable. To delineate the role of leukemic translocation NUP98-HOXD13 (...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Leuk Res
Prif Awduron: Puthiyaveetil, Abdul Gafoor, Reilly, Christopher M., Pardee, Timothy S., Caudell, David L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881388/
https://ncbi.nlm.nih.gov/pubmed/23131583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2012.10.012
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