Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer

PURPOSE: TH-302 is an investigational hypoxia-activated prodrug that releases the DNA alkylator bromo-isophosphoramide mustard in hypoxic settings. This phase II study (NCT01144455) evaluated gemcitabine plus TH-302 in patients with previously untreated, locally advanced or metastatic pancreatic can...

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Foilsithe in:J Clin Oncol
Main Authors: Borad, Mitesh J., Reddy, Shantan G., Bahary, Nathan, Uronis, Hope E., Sigal, Darren, Cohn, Allen L., Schelman, William R., Stephenson, Joe, Chiorean, E. Gabriela, Rosen, Peter J., Ulrich, Brian, Dragovich, Tomislav, Del Prete, Salvatore A., Rarick, Mark, Eng, Clarence, Kroll, Stew, Ryan, David P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881365/
https://ncbi.nlm.nih.gov/pubmed/25512461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.55.7504
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