Stable Domain Assembly of a Monomolecular DNA Quadruplex: Implications for DNA-Based Nanoswitches

In the presence of K(+) ions, the 5′-GGGTGGGTGGGTGGG-3′ (G3T) sequence folds into a monomolecular quadruplex with unusually high thermal stability and unique optical properties. In this study we report that although single G3T molecules unfold and fold rapidly with overlapping melting and refolding...

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Bibliografske podrobnosti
izdano v:Biophys J
Main Authors: Kankia, Besik, Gvarjaladze, David, Rabe, Adam, Lomidze, Levan, Metreveli, Nunu, Musier-Forsyth, Karin
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2016
Teme:
Nucleic Acids and Genome Biophysics Proteins
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880955/
https://ncbi.nlm.nih.gov/pubmed/27224482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.031
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