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New treatment option for ovarian cancer: PARP inhibitors
Poly(ADP-ribose) polymerase (PARP), which was first described over 50 years ago by Mandel, are a family of protein enzymes involved in DNA damage response and works by recognizing the single-strand DNA break (ssDNA) and then effecting DNA repair. A double-strand DNA (dsDNA) break can be repaired by...
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| 發表在: | Gynecol Oncol Res Pract |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4880823/ https://ncbi.nlm.nih.gov/pubmed/27231574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40661-016-0024-7 |
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