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Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease

Human LRRK2 (Leucine-Rich Repeat Kinase 2) has been associated with both familial and idiopathic Parkinson's disease (PD). Although several LRRK2 mediated pathways and interaction partners have been identified, the cellular functions of LRRK2 and LRRK2 mediated progression of PD are still only...

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Detalhes bibliográficos
Publicado no:Parkinsons Dis
Main Authors: Rosenbusch, Katharina E., Kortholt, Arjan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880697/
https://ncbi.nlm.nih.gov/pubmed/27293958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/7351985
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