The Arg59Trp variant in ANGPTL8 (Betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3

We previously identified a locus linked to total cholesterol (TC) concentration in Pima Indians on chromosome 19p. To characterize this locus, we genotyped >2000 SNPs in 1838 Pimas and assessed association with log(TC). We observed evidence for association with log(TC) with rs2278426 (3.5% decrea...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab
Main Authors: Hanson, Robert L., Leti, Fatjon, Tsinajinnie, Darwin, Kobes, Sayuko, Puppala, Sobha, Curran, Joanne E., Almasy, Laura, Lehman, Donna M., Blangero, John, Duggirala, Ravindranath, DiStefano, Johanna K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880492/
https://ncbi.nlm.nih.gov/pubmed/27117576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2016.04.007
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