Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis

In this study, we aim to identify environmental molecules that can inhibit cholesterol biosynthesis, potentially leading to the same biochemical defects as observed in cholesterol biosynthesis disorders, which are often characterized by congenital malformations and developmental delay. Using the Dis...

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Détails bibliographiques
Publié dans:Toxicol Sci
Auteurs principaux: Herron, Josi, Reese, Rosalyn C., Tallman, Keri A., Narayanaswamy, Rohini, Porter, Ned A., Xu, Libin
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Identification of Cholesterol Biosynthesis Inhibitors
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880132/
https://ncbi.nlm.nih.gov/pubmed/26919959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw041
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