Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis

In this study, we aim to identify environmental molecules that can inhibit cholesterol biosynthesis, potentially leading to the same biochemical defects as observed in cholesterol biosynthesis disorders, which are often characterized by congenital malformations and developmental delay. Using the Dis...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Herron, Josi, Reese, Rosalyn C., Tallman, Keri A., Narayanaswamy, Rohini, Porter, Ned A., Xu, Libin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Identification of Cholesterol Biosynthesis Inhibitors
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880132/
https://ncbi.nlm.nih.gov/pubmed/26919959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw041
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