β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans

CONTEXT: Insulin resistance impacts virtually all tissues, including pancreatic β cells. Individuals with insulin resistance, but without diabetes, exhibit an increased islet size because of an elevated number of both β and α cells. Neogenesis from duct cells and transdifferentiation of α cells have...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Mezza, Teresa, Sorice, Gian P., Conte, Caterina, Sun, Vinsin A., Cefalo, Chiara M. A., Moffa, Simona, Pontecorvi, Alfredo, Mari, Andrea, Kulkarni, Rohit N., Giaccari, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880124/
https://ncbi.nlm.nih.gov/pubmed/26649619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2015-2802
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