Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

HIGHLIGHTS: ASS234 is a MTDL compound containing a moiety from Donepezil and the propargyl group from the PF 9601N, a potent and selective MAO B inhibitor. This compound is the most advanced anti-Alzheimer agent for preclinical studies identified in our laboratory. Derived from ASS234 both multipote...

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Bibliografiske detaljer
Udgivet i:Front Neurosci
Main Authors: Unzeta, Mercedes, Esteban, Gerard, Bolea, Irene, Fogel, Wieslawa A., Ramsay, Rona R., Youdim, Moussa B. H., Tipton, Keith F., Marco-Contelles, José
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879129/
https://ncbi.nlm.nih.gov/pubmed/27252617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2016.00205
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