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The TBK1 binding domain of optineurin promotes type I interferon responses
Pathogen-associated molecular pattern (PAMP) recognition leads to TANK-binding kinase (TBK1) polyubiquitination and activation by trans-autophosphorylation, resulting in IFN-β production. Here we describe a mouse model of optineurin insufficiency (OptnΔ(157)) in which the TBK1-interacting N-terminus...
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| Publicado no: | FEBS Lett |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4879041/ https://ncbi.nlm.nih.gov/pubmed/27086836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12176 |
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