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Cryptic sequence features within the disordered protein p27(Kip1) regulate cell cycle signaling

Peptide motifs embedded within intrinsically disordered regions (IDRs) of proteins are often the sites of posttranslational modifications that control cell-signaling pathways. How do IDR sequences modulate the functionalities of motifs? We answer this question using the polyampholytic C-terminal IDR...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Das, Rahul K., Huang, Yongqi, Phillips, Aaron H., Kriwacki, Richard W., Pappu, Rohit V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878473/
https://ncbi.nlm.nih.gov/pubmed/27140628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516277113
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