Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

Restoring functional β-cell mass is an important therapeutic goal for both type 1 and type 2 diabetes (1). While proliferation of existing β-cells is the primary means of β-cell replacement in rodents (2), it is unclear whether a similar principle applies to humans, as human β-cells are remarkably r...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Dirice, Ercument, Walpita, Deepika, Vetere, Amedeo, Meier, Bennett C., Kahraman, Sevim, Hu, Jiang, Dančík, Vlado, Burns, Sean M., Gilbert, Tamara J., Olson, David E., Clemons, Paul A., Kulkarni, Rohit N., Wagner, Bridget K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878416/
https://ncbi.nlm.nih.gov/pubmed/26953159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1127
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