Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma

PURPOSE: Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles. PATIENTS AND METHODS: We determined subgroup affiliation, TP53 mutation status, and clinical outcome in a d...

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Veröffentlicht in:J Clin Oncol
Hauptverfasser: Zhukova, Nataliya, Ramaswamy, Vijay, Remke, Marc, Pfaff, Elke, Shih, David J.H., Martin, Dianna C., Castelo-Branco, Pedro, Baskin, Berivan, Ray, Peter N., Bouffet, Eric, von Bueren, André O., Jones, David T.W., Northcott, Paul A., Kool, Marcel, Sturm, Dominik, Pugh, Trevor J., Pomeroy, Scott L., Cho, Yoon-Jae, Pietsch, Torsten, Gessi, Marco, Rutkowski, Stefan, Bognar, Laszlo, Klekner, Almos, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Eberhart, Charles G., Fevre-Montange, Michelle, Fouladi, Maryam, French, Pim J., Kros, Max, Grajkowska, Wieslawa A., Gupta, Nalin, Weiss, William A., Hauser, Peter, Jabado, Nada, Jouvet, Anne, Jung, Shin, Kumabe, Toshihiro, Lach, Boleslaw, Leonard, Jeffrey R., Rubin, Joshua B., Liau, Linda M., Massimi, Luca, Pollack, Ian F., Shin Ra, Young, Van Meir, Erwin G., Zitterbart, Karel, Schüller, Ulrich, Hill, Rebecca M., Lindsey, Janet C., Schwalbe, Ed C., Bailey, Simon, Ellison, David W., Hawkins, Cynthia, Malkin, David, Clifford, Steven C., Korshunov, Andrey, Pfister, Stefan, Taylor, Michael D., Tabori, Uri
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878050/
https://ncbi.nlm.nih.gov/pubmed/23835706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.48.5052
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