The F309S mutation increases factor VIII secretion in human cell line

OBJECTIVES: The capacity of a human cell line to secrete recombinant factor VIII with a F309S point mutation was investigated, as was the effect of the addition of chemical chaperones (betaine and sodium-4-phenylbutyrate) on the secretion of factor VIII. METHODS: This work used a vector with a F309S...

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Publicat a:Rev Bras Hematol Hemoter
Autors principals: Fantacini, Daianne Maciely Carvalho, Fontes, Aparecida Maria, de Abreu Neto, Mário Soares, Covas, Dimas Tadeu, Picanço-Castro, Virgínia
Format: Artigo
Idioma:Inglês
Publicat: Sociedade Brasileira de Hematologia e Hemoterapia 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877930/
https://ncbi.nlm.nih.gov/pubmed/27208572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bjhh.2016.04.002
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