Reduced expression of APC-1B but not APC-1A by the deletion of promoter 1B is responsible for familial adenomatous polyposis

Germline mutations in the tumor suppressor gene APC are associated with familial adenomatous polyposis (FAP). Here we applied whole-genome sequencing (WGS) to the DNA of a sporadic FAP patient in which we did not find any pathological APC mutations by direct sequencing. WGS identified a promoter del...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yamaguchi, Kiyoshi, Nagayama, Satoshi, Shimizu, Eigo, Komura, Mitsuhiro, Yamaguchi, Rui, Shibuya, Tetsuo, Arai, Masami, Hatakeyama, Seira, Ikenoue, Tsuneo, Ueno, Masashi, Miyano, Satoru, Imoto, Seiya, Furukawa, Yoichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877598/
https://ncbi.nlm.nih.gov/pubmed/27217144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26011
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