Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.
The raf genes encode a family of cytoplasmic proteins with intrinsic protein-serine/threonine kinase activity. The c-raf gene is the cellular homolog of v-raf, the transforming gene of murine sarcoma virus 3611. The constitutive kinase activity of the v-Raf protein has been implicated in transformat...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1372995/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.2922 |
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