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Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.

The raf genes encode a family of cytoplasmic proteins with intrinsic protein-serine/threonine kinase activity. The c-raf gene is the cellular homolog of v-raf, the transforming gene of murine sarcoma virus 3611. The constitutive kinase activity of the v-Raf protein has been implicated in transformat...

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Bibliographic Details
Main Authors: Williams, N G, Roberts, T M, Li, P
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC48775/
https://ncbi.nlm.nih.gov/pubmed/1372995
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