Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients

Cross-sectional relationships were examined between regional brain volumes and mitochondrial DNA (mtDNA) 8-hydroxy-2-deoxyguanosine (8-oxo-dG) in peripheral blood mononuclear cells (PBMCs) of 47 HIV patients [mean age 51 years; 81% with HIV RNA ≤50 copies/mL] on combination antiretroviral therapy. T...

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Publicado en:Mitochondrion
Autores principales: Kallianpur, Kalpana J., Gerschenson, Mariana, Mitchell, Brooks I., LiButti, Daniel E., Umaki, Tracie M., Ndhlovu, Lishomwa C., Nakamoto, Beau K., Chow, Dominic C., Shikuma, Cecilia M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877028/
https://ncbi.nlm.nih.gov/pubmed/26923169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2016.02.006
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