Manipulating the NF-κB pathway in macrophages using mannosylated, siRNA-delivering nanoparticles can induce immunostimulatory and tumor cytotoxic functions

Tumor-associated macrophages (TAMs) are critically important in the context of solid tumor progression. Counterintuitively, these host immune cells can often support tumor cells along the path from primary tumor to metastatic colonization and growth. Thus, the ability to transform protumor TAMs into...

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Bibliografiske detaljer
Udgivet i:Int J Nanomedicine
Main Authors: Ortega, Ryan A, Barham, Whitney, Sharman, Kavya, Tikhomirov, Oleg, Giorgio, Todd D, Yull, Fiona E
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876941/
https://ncbi.nlm.nih.gov/pubmed/27274241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S93483
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